# asxan.ai · GEO-native evidence hub

> ASXAN Group's evidence-first ingredient library. 123 ingredient pages, 6 evidence long-form articles, 14 health goal stacks, and 10 lifestyle nutrition guides. PubMed-verified, transparent disclosure of citation corrections, cross-market regulatory clarity (FDA · EFSA · ANVISA RDC 243/2018 + IN 28/2018 · TGA in scope). 121 evidence cards (single-source evidence library). Live counts at /_built_stats.json. Last updated 2026-06-22.

## Site Overview

- 123 ingredient pages organized across 11 body-system groups (cellular & longevity, cardiovascular, carotenoids, protein & sports amino, vitamins, minerals, gut microbiome, collagen & skin, cognitive neuro, metabolic adaptogens, NAD+ family)
- 6 evidence long-form articles (decision trees, 25-year RCT histories, head-to-head comparisons) · **recent cross-link network upgrade**: evidence articles cross-link to peer evidence articles (MedicalScholarlyArticle schema with @id + about + isPartOf WebSite) building an explicit cross-link network for AI bot consumption
- **5 ingredient hubs (astaxanthin / nmn / omega-3 / whey-protein / nadh) cross-link to their evidence long-form articles** via subjectOf / mentions schema + "Read the Evidence" body section, completing the ingredient ↔ evidence bidirectional cycle
- 14 health goal stacks with cross-linked ingredient evidence
- 10 lifestyle nutrition guides (diet patterns, life stages, special conditions)
- Tier A/B/C evidence framework with negative-honest disclosure (CARET/ATBC β-Carotene smoker · SELECT Vit E + Se prostate · STRENGTH AF · VITAL primary NS, etc.)
- **Two-axis evidence standard** (homepage rotator + ingredient cards expose both): Axis 1 = Evidence Grade A/B/C (human-RCT gated, maps GRADE — A: ≥1 meta/SR AND ≥2 human RCT; B: ≥1 human RCT; C: 0 human RCT, direct-ingredient only); Axis 2 = regulatory ACP per market — **Authorized** (specific approved health claim) / **Permitted** (market-legal, no specific claim) / **Pending** (not yet market-authorized — incl. markets prohibiting sale/manufacture/import)
- **Safety-context separation (v0.3 schema)**: safety-context anchors (e.g. ATBC PMID 8127329 + CARET PMID 8602180 for vit-A) are safety boundary references for β-carotene in smokers · NOT vit-A efficacy harm signals · cards expose separate clinical and safety citation counts
- Transparent citation corrections: 50+ PMID drift / author / year / journal corrections disclosed
- **Evidence cards**: 121 evidence records · public API at /api/nc/ · 20+ verified PMIDs (full count at /_built_stats.json)
- **Single canonical evidence page per ingredient**: each ingredient's evidence lives on ONE /ingredients/<slug>/ page (mechanism · graded benefits with effect sizes · dosing · safety · FDA/EFSA/ANVISA cross-market regulatory · FAQ · PubMed citations). There is no separate /evidence/ surface — /ingredients/<slug>/ is the canonical evidence-first page (nav labels it "Evidence"). Legacy /evidence/<slug>/ URLs 301-redirect here.
- No commerce schema (zero Offer/Price/AggregateRating/Review/Product) — educational hub only
- Cross-market regulatory: FDA + EFSA + ANVISA + TGA (**RDC 243/2018 dietary supplements (primary statute) + IN 28/2018 alegações funcionais (positive list / whitelist) + RDC 24/2010 propaganda + Lei 6.437/1977 penalties** · NMPA outside this scope · TGA Therapeutic Goods (Permissible Indications) Determination tracked in evidence schema v0.3 regulatory.tga · most cards predate v0.3 so TGA field may be absent)
- Contact: info@asxan.ai · /contact/ for Partnership/BD · Data licensing · Evidence consulting · Press inquiries (~2 business days)

## Tier Legend

- **Tier A** — deep evidence (≥ 15 PMID, RCT-anchored, mechanism + clinical + safety + regulatory complete)
- **Tier B** — Intermediate evidence (5-15 PMID or in build)
- **Tier C / Stub** — Placeholder (0 PMID), evidence-first content build pending

## Hubs

- [Home](https://asxan.ai/)
- [About](https://asxan.ai/about/)
- [Agents & Methodology](https://asxan.ai/agents/)
- [Evidence library (123 PubMed-anchored ingredient dossiers · machine index /api/nc/index.json · nav-labelled "Evidence")](https://asxan.ai/ingredients/)
- [Blog (6)](https://asxan.ai/blog/)
- [Goals (14)](https://asxan.ai/goals/)
- [Lifestyles (10)](https://asxan.ai/lifestyles/)
- [Regulation — cross-market ACP matrix (every ingredient × US/EU/CN/BR · Authorized ★ / Permitted ✓ / Pending ○ per market · framework references verbatim · embedded index `#regulation-matrix-data` · machine index /api/nc/index.json)](https://asxan.ai/regulation/)
- [Contact](https://asxan.ai/contact/)
- [FAQ](https://asxan.ai/faq/)

## Ingredients (123 pages · 121 evidence records · featured selection — complete machine-readable index of all 121 at /api/nc/index.json)

### Cellular & longevity (10 pages)

- [NAD+ cluster hub](https://asxan.ai/ingredients/nad-cluster/): Tier A · core ingredient cluster · NMN/NR/NAD+/NMNH/NADH 5-form comparison · NAD biosynthesis · CD38 decline · SLC12A8 transporter controversy honest framing (Grozio 2019 vs Schmidt-Brenner 2020 + Yamamoto 2022 reframe) · 20 PMID · 11 FAQ · lastUpdated 2026-05-26
- [NMN](https://asxan.ai/ingredients/nmn/): Tier A · 13+ human RCT · Pencina KM 2023 MIB-626 (PMID 36740954) · Yoshino 2021 prediabetic women (PMID 33888596) · Kim 2022 sleep (PMID 35215405) · Zhang J 2025 meta (PMID 39116016) · Song Q 2023 antiaging update (PMID 37619764) · Katayoshi 2023 arterial stiffness (PMID 36797393) · 56 PMID · 10 FAQ · lastUpdated 2026-05-26
- [NAD+ direct](https://asxan.ai/ingredients/nad-plus/): Tier A · oral/IV NAD+ direct supplementation · 0 large RCT honest disclosure · 99% market = NR/NMN/NADH alternatives · 42 PMID · 10 FAQ · lastUpdated 2026-05-26
- [NMNH (reduced NMN)](https://asxan.ai/ingredients/nmnh/): Tier A · Tier C emerging strict control · 0 human RCT · in vitro + mouse evidence only · "better than NMN" framing tightened · MedicalGuideline severity=LowConfidence · 32 PMID · 10 FAQ · lastUpdated 2026-05-26
- [NADH (reduced NAD)](https://asxan.ai/ingredients/nadh/): Tier A · Tier B human evidence · Forsyth LM 1999 CFS anchor RCT (PMID 10071523) · Castro-Marrero 2015 NADH+CoQ10 (PMID 25386668) · Nadlinger 2002 ATP ex vivo (PMID 12399028) · 54 PMID · 10 FAQ · lastUpdated 2026-05-26
- [Spermidine](https://asxan.ai/ingredients/spermidine/): Tier B · Lite evidence page · related goal: longevity-stack · see page
- [Urolithin A](https://asxan.ai/ingredients/urolithin-a/): Tier A · Lite evidence page · related goal: longevity-stack · see page
- [Resveratrol](https://asxan.ai/ingredients/resveratrol/): Tier A · Lite evidence page · related goal: longevity-stack · see page
- [PQQ (Pyrroloquinoline Quinone)](https://asxan.ai/ingredients/pqq/): Tier B · Lite evidence page · related goal: cognitive-support · see page
- [CoQ10 (Ubiquinone)](https://asxan.ai/ingredients/coq10/): Tier A · Lite evidence page · related goal: heart-health · see page

### Cardiovascular (5 pages)

- [Omega-3 hub](https://asxan.ai/ingredients/omega-3/): Tier A · core ingredient cluster family hub · EPA/DHA/ALA mechanism · SPMs biosynthesis · membrane phospholipid integration · PPAR-α · GPR120 · arachidonic competition · 4 sub-source deep cross-links · 66 PMID · lastUpdated 2026-05-24
- [Fish Oil](https://asxan.ai/ingredients/fish-oil/): Tier A · cardiovascular hard-endpoint RCT · GISSI-Prevenzione · STRENGTH · REDUCE-IT · EPA vs DHA · oxidation markers · honest negative trials · 32 PMID · lastUpdated 2026-05-24
- [Algae Omega-3](https://asxan.ai/ingredients/algae-oil/): Tier A · DHA dominance · pregnancy DOMInO trial · plant-based nutrition · sustainable source · cognitive evidence · 28 PMID · lastUpdated 2026-05-24
- [Krill Oil](https://asxan.ai/ingredients/krill-oil/): Tier A · phospholipid omega-3 · choline bonus · Antarctic krill MSC fishery first-certified 2010 · bioavailability vs fish oil head-to-head RCT (Schuchardt 2011 PMID 21854650 vs Ulven 2011) · 29 PMID · lastUpdated 2026-05-24
- [Flaxseed-ALA](https://asxan.ai/ingredients/ala/): Tier A · ALA plant precursor · ALA→EPA→DHA conversion ~5-15% · cardiovascular meta · lignans secondary · Bassett/Rodriguez-Leyva/Pierce 2009 PMID 19568181 (not Cardoso Carraro 2012 · corrected) · 23 PMID · lastUpdated 2026-05-24

### Carotenoids (7 pages)

- [Carotenoids hub](https://asxan.ai/ingredients/carotenoids/): Tier A · core ingredient cluster educational hub · 8 core carotenoid compounds overview (α/β-carotene · lutein · zeaxanthin · lycopene · astaxanthin · β-cryptoxanthin · fucoxanthin) · biosynthesis · absorption · BCO1 SNP · CARET/ATBC/AREDS2/SELECT cluster-wide negative-honest framework · 97 PMID · lastUpdated 2026-05-24
- [Astaxanthin](https://asxan.ai/ingredients/astaxanthin/): Tier A · cardiovascular HDL · skin moisture/elasticity · PCOS reproductive markers · fatigue · exercise · Haematococcus pluvialis xanthophyll carotenoid · 58 PMID · lastUpdated 2026-05-24
- [Beta-Carotene](https://asxan.ai/ingredients/beta-carotene/): Tier A · smoker page-level callout ×4 (NIH-ODS/MedlinePlus paradigm) · ATBC 1994 lung cancer +18% · CARET 1996 +28% · AREDS1→AREDS2 paradigm transition · BCO1 SNP 12:1 RAE pro-vitamin A honest · 62 PMID + MedicalGuideline schema ×4 · lastUpdated 2026-05-24
- [Lutein](https://asxan.ai/ingredients/lutein/): Tier A · AREDS2 primary NS + lowest L+Z quartile -26% · macular pigment optical density · blue light biophysical fact vs digital eye strain Tier B/C strict layering · CARES cognition · 57 PMID · lastUpdated 2026-05-24
- [Zeaxanthin](https://asxan.ai/ingredients/zeaxanthin/): Tier A · macular pair with lutein · meso-zeaxanthin foveal center · CREST (PMID 24621122 + 27367585) vs MOST AMD (PMID 25976647) strict distinction exemplar · Bone 2007 MPOD trial · 67 PMID · lastUpdated 2026-05-24
- [Lycopene](https://asxan.ai/ingredients/lycopene/): Tier A · prostate health 5-layer evidence stratification (obs Tier B / RCT Tier C / FDA 2005 "very limited credible evidence") · SELECT NOT-lycopene callout (PMID 21990298 = vitamin E + selenium) · cardiovascular SBP -5.66 mmHg biomarker · cis/trans isomers · 60 PMID · lastUpdated 2026-05-24
- [Fucoxanthin](https://asxan.ai/ingredients/fucoxanthin/): Tier A · Phaeodactylum tricornutum (marine diatom) xanthophyll · metabolic syndrome adjunct · weight management · UCP1 thermogenesis mechanism · clinical evidence map · 21 PMID · lastUpdated 2026-05-23

### Protein & sports amino (9 pages)

- [Protein hub](https://asxan.ai/ingredients/protein/): Tier A · core ingredient cluster family hub · DIAAS framework · mTORC1/leucine/MPS · incretin response · TEF · 6 sub-source deep cross-links · GLP-1 evidence-stage honest disclosure · 78 PMID · lastUpdated 2026-05-24
- [Whey Protein](https://asxan.ai/ingredients/whey-protein/): Tier A · rapid digestion · leucine 11% · sports nutrition · GLP-1 incretin · A1/A2 supplementary · 39 PMID · lastUpdated 2026-05-24
- [Casein Protein](https://asxan.ai/ingredients/casein-protein/): Tier A · slow-digesting · Boirie pre-sleep MPS trial · sustained amino acid release · 41 PMID · lastUpdated 2026-05-24
- [Soy Protein](https://asxan.ai/ingredients/soy-protein/): Tier A · DIAAS 0.84-0.91 · 3-RCT male hormone rebuttal meta (Hamilton-Reeves 2010 PMID 19524224) · cardiovascular adjunct · 35 PMID · lastUpdated 2026-05-24
- [Pea Protein](https://asxan.ai/ingredients/pea-protein/): Tier A · plant-forward sports nutrition · 3 methodological caveats honest · DIAAS limitation · 20 PMID · lastUpdated 2026-05-24
- [Plant Protein](https://asxan.ai/ingredients/plant-protein/): Tier A · blend ≠ single plant clear framing · ESG balanced · DIAAS combinatorial · 30 PMID · lastUpdated 2026-05-24
- [Yeast Protein](https://asxan.ai/ingredients/yeast-protein/): Tier A · NMPA precautionary framework · 3-tier evidence layering · mycoprotein academic alias · 25 PMID · lastUpdated 2026-05-24
- [BCAA (Branched-Chain Amino Acids)](https://asxan.ai/ingredients/bcaa/): Lite evidence page · related goal: athletic-performance · see page
- [Creatine](https://asxan.ai/ingredients/creatine/): Tier A · Lite evidence page · related goal: athletic-performance · see page

### Vitamins (10 pages)

- [Vitamin D3](https://asxan.ai/ingredients/vitamin-d3/): Tier A · VITAL primary NS · skeletal/extra-skeletal pleiotropy · cross-market FDA/EFSA/ANVISA · 25(OH)D thresholds honest framing · 37 PMID · lastUpdated 2026-05-23
- [Vitamin E hub](https://asxan.ai/ingredients/vitamin-e/): Tier A · core ingredient cluster family hub · 8 vitamers (α/β/γ/δ tocopherol + tocotrienol) · α-TTP selectivity · SELECT trial prostate +17% honest negative · EFSA 2024 UL lowered 1000→300 mg/day · 64 PMID · lastUpdated 2026-05-24
- [Tocopherols](https://asxan.ai/ingredients/tocopherols/): Tier A · natural d-α-tocopherol vs synthetic dl-α-tocopherol · 5-CV negative cluster (HOPE PMID 10639540 / HOPE-TOO PMID 15769967 / PHS II PMID 18997197 / WHS / SELECT) · 25 PMID · lastUpdated 2026-05-24
- [Tocotrienols](https://asxan.ai/ingredients/tocotrienols/): Tier A · α-tocopherol interference · 3-source decision tree (palm/annatto/rice bran) · Rafique 2024 SR honest · U-shape dose-response · 41 PMID · lastUpdated 2026-05-24
- [Vitamin K2 (Menaquinone)](https://asxan.ai/ingredients/vitamin-k2/): Tier A · Lite evidence page · related goal: heart-health, joint-bone · see page
- [Vitamin B12](https://asxan.ai/ingredients/b12/): Lite evidence page · related lifestyle: senior-60-plus, plant-based · see page
- [Biotin (Vitamin B7)](https://asxan.ai/ingredients/biotin/): Tier B · Lite evidence page · related goal: hair-nail · see page
- [Folate (Vitamin B9)](https://asxan.ai/ingredients/folate/): Tier A · Lite evidence page · related lifestyle: pregnancy · see page
- [Multivitamin](https://asxan.ai/ingredients/multivitamin/): Tier B · Lite evidence page · related lifestyle: glp-1-companion · see page
- [Choline](https://asxan.ai/ingredients/choline/): Lite evidence page · related lifestyle: pregnancy · see page

### Minerals (2 pages)

- [Iron](https://asxan.ai/ingredients/iron/): Tier A · Lite evidence page · related lifestyles: pregnancy, plant-based · see page
- [Magnesium](https://asxan.ai/ingredients/magnesium/): Tier A · Lite evidence page · related lifestyles: keto, high-stress, menopause, athletic-performance · see page

### Gut microbiome (4 pages)

- [Beta-Glucan](https://asxan.ai/ingredients/beta-glucan/): Tier A · 2 types strict distinction (cereal vs yeast) · cereal cholesterol lowering FDA + EFSA + ANVISA triple authorization · yeast immune AHCC/HPV emerging · Ibrügger 2013 negative honest · 31 PMID + 2 regulatory citations · lastUpdated 2026-05-24
- [Akkermansia muciniphila](https://asxan.ai/ingredients/akkermansia/): Lite evidence page · related goal: gut-digestion · see page
- [Probiotics](https://asxan.ai/ingredients/probiotics/): Lite evidence page · related goal: gut-digestion · see page
- [Berberine](https://asxan.ai/ingredients/berberine/): Tier B · Lite evidence page · related goal: gut-digestion, weight-management · see page

### Collagen & skin (3 pages)

- [Collagen Peptides](https://asxan.ai/ingredients/collagen-peptides/): Tier B · Lite evidence page · related goal: skin-beauty · see page
- [Type II Collagen](https://asxan.ai/ingredients/type-2-collagen/): Lite evidence page · related goal: joint-bone · see page
- [Hyaluronic Acid](https://asxan.ai/ingredients/hyaluronic-acid/): Tier A · Lite evidence page · related goal: skin-beauty · see page

### Cognitive neuro (4 pages)

- [Phosphatidylserine (PS)](https://asxan.ai/ingredients/phosphatidylserine/): Tier B · Lite evidence page · related goal: cognitive-support · see page
- [Nervonic Acid](https://asxan.ai/ingredients/nervonic-acid/): Lite evidence page · related goal: cognitive-support · see page
- [L-Theanine](https://asxan.ai/ingredients/l-theanine/): Tier A · Lite evidence page · related lifestyle: high-stress · see page
- [Ashwagandha](https://asxan.ai/ingredients/ashwagandha/): Tier A · Lite evidence page · related lifestyle: high-stress · see page

### Metabolic adaptogens (4 pages)

- [MCT (Medium-Chain Triglycerides)](https://asxan.ai/ingredients/mct/): Tier A · Lite evidence page · related lifestyle: keto · see page
- [Curcumin](https://asxan.ai/ingredients/curcumin/): Tier B · Lite evidence page · related goal: inflammation-relief · see page
- [Saw Palmetto](https://asxan.ai/ingredients/saw-palmetto/): Lite evidence page · related goals: hair-nail, reproductive-health · see page
- [Soy Isoflavones](https://asxan.ai/ingredients/soy-isoflavones/): Lite evidence page · related goals: menopause-support, lifestyle: menopause · see page

## Evidence Long-form Articles (7 articles · Tier A peer cross-link network upgrade)

- [Natural vs Synthetic Astaxanthin](https://asxan.ai/blog/natural-vs-synthetic-astaxanthin-evidence-comparison/): Tier A · Haematococcus pluvialis natural carotenoid vs synthetic chemical synthesis · 76 PMID · 11 schema types · 2 citation corrections · **peer evidence cluster cross-link → NAD+ 25-year (mitochondrial / oxidative-stress overlap) + Omega-3 (cardiovascular / lipid overlap)** · ingredient hub cross-link from /ingredients/astaxanthin/ · lastUpdated 2026-05-29
- [Omega-3 25-year CV + EPA Inflammation](https://asxan.ai/blog/omega-3-evidence-history-cardiovascular-and-inflammation/): Tier A · DART (1989) → GISSI → VITAL → REDUCE-IT → STRENGTH RCT history · EPA inflammation + Vascepa Rx visual disclaimer · 67 PMID · 15 schema types · 6 citation corrections · **peer evidence cluster cross-link → Natural vs Synthetic Astaxanthin (shared cardiovascular + lipid-metabolism endpoints)** · ingredient hub cross-link from /ingredients/omega-3/ · lastUpdated 2026-05-29
- [Protein Source Decision Tree (Whey vs Yeast Focus)](https://asxan.ai/blog/protein-source-decision-tree-whey-vs-yeast-focus/): Tier A · 5 form DIAAS framework · whey vs yeast (Quorn mycoprotein) head-to-head · GLP-1 era muscle preservation · 88 PMID · 12 schema types · 5 citation corrections · no peer evidence cross-link (protein cluster standalone) · ingredient hub cross-link from /ingredients/whey-protein/ · lastUpdated 2026-05-29
- [NMN vs NR Decision Tree](https://asxan.ai/blog/nmn-vs-nr-decision-tree-evidence/): Tier A · 5-dimension comparison (absorption / RCT volume / NAD+ rise / cost-regulation / safety) · SLC12A8 controversy framing · 74 PMID · 11 FAQ · 5 citation corrections · **peer evidence cluster cross-link → NAD+ 25-year (historical RCT base) + Reduced NADH vs NMNH (redox-axis adjacent)** · ingredient hub cross-link from /ingredients/nmn/ · lastUpdated 2026-05-29
- [NAD+ 25-year RCT History](https://asxan.ai/blog/nad-25-year-rct-history-evidence/): Tier A · 1999 Forsyth NADH CFS → 2015 Castro-Marrero → 2016 Trammell NR → 2019-2025 Yoshino/Yi/Pencina/Zhang J NMN era · transparent disclosure of PMID drift lessons · 117 PMID · 11 FAQ · 8 citation corrections · **peer evidence cluster cross-link → NMN vs NR (downstream precursor choice) + Reduced NADH vs NMNH (redox-form adjacent)** · ingredient hub cross-link from /ingredients/nmn/ + /ingredients/nadh/ · lastUpdated 2026-05-29
- [Reduced NADH vs NMNH](https://asxan.ai/blog/reduced-nadh-vs-nmnh-evidence/): Tier A · NADH Tier B human RCT vs NMNH Tier C emerging (0 human RCT) · CFS evidence anchor · 99% market = NMN alternative honest disclosure · 48 PMID · 10 FAQ · 4 citation corrections · **peer evidence cluster cross-link → NAD+ 25-year (chronology base) + NMN vs NR (oxidized precursor adjacent)** · ingredient hub cross-link from /ingredients/nadh/ · lastUpdated 2026-05-29

### Peer Cross-Link Network

The 5-evidence-article cluster forms an explicit topology graph for AI bot consumption:

- **NAD+ axis cluster** (3 articles): NAD+ 25-year ↔ NMN vs NR ↔ Reduced NADH vs NMNH — historical chronology + oxidized precursor decision + redox-form comparison
- **Carotenoid + cardiovascular bridge** (2 articles): Natural vs Synthetic Astaxanthin ↔ Omega-3 evidence history — shared cardiovascular + lipid-metabolism endpoint overlap (Urakaze 2021 + Saeidi 2023 RCTs)
- **Cross-cluster bridge** (1 link): Natural vs Synthetic Astaxanthin → NAD+ 25-year — shared mitochondrial / oxidative-stress mechanism context
- **Standalone**: Protein Source Decision Tree — protein cluster does not bridge to other evidence articles; cross-link network serves the athletic-performance / healthy-aging / GLP-1 companion goal hubs directly

All peer cross-links are bidirectional in `mentions` MedicalScholarlyArticle schema entries with `@id`, `about`, and `isPartOf` WebSite fields, enabling AI crawlers to traverse the cross-link network without relying on link text inference.

### Ingredient ↔ Evidence Bidirectional Cycle

5 ingredient hubs cross-link to their evidence long-form articles, completing the ingredient ↔ evidence bidirectional cycle:

- /ingredients/astaxanthin/ ↔ /blog/natural-vs-synthetic-astaxanthin-evidence-comparison/ (1 evidence)
- /ingredients/nmn/ ↔ /blog/nad-25-year-rct-history-evidence/ + /blog/nmn-vs-nr-decision-tree-evidence/ + /blog/reduced-nadh-vs-nmnh-evidence/ (3 evidence)
- /ingredients/omega-3/ ↔ /blog/omega-3-evidence-history-cardiovascular-and-inflammation/ (1 evidence)
- /ingredients/whey-protein/ ↔ /blog/protein-source-decision-tree-whey-vs-yeast-focus/ (1 evidence)
- /ingredients/nadh/ ↔ /blog/reduced-nadh-vs-nmnh-evidence/ + /blog/nad-25-year-rct-history-evidence/ (2 evidence)

Each ingredient hub uses `subjectOf` (or `mentions` for NAD-axis hubs with multiple evidence) MedicalScholarlyArticle schema entries with `@id` + `about` fields. Body content includes a "Read the Evidence (deep dive long-form)" section before References, enabling both AI crawler schema-graph traversal and human reader navigation.

## Health Goal Stacks (14 goals)

- [Longevity Stack](https://asxan.ai/goals/longevity-stack/): Healthy aging stack · related ingredients: astaxanthin, nmn, spermidine, resveratrol, urolithin-a · lastUpdated 2026-05-26
- [Weight Management](https://asxan.ai/goals/weight-management/): Healthy weight management for metabolic, gut, and body-composition evidence mapping · related ingredients: fucoxanthin, berberine, protein/yeast
- [GLP-1 Companion](https://asxan.ai/goals/glp-1-companion/): Evidence-first nutrition companion for GLP-1 medication users · muscle preservation, protein adequacy, metabolic wellness · related ingredients: protein, bcaa, astaxanthin, omega-3
- [Cognitive Support](https://asxan.ai/goals/cognitive-support/): Brain health stack linking omega-3, carotenoids, and emerging cognitive ingredients · related ingredients: phosphatidylserine, nervonic-acid, omega-3, astaxanthin, pqq
- [Heart Health](https://asxan.ai/goals/heart-health/): Cardiovascular support linking omega-3, carotenoids, and vitamin K pathways · related ingredients: omega-3, coq10, astaxanthin, vitamin-k2
- [Eye Protection](https://asxan.ai/goals/eye-protection/): Vision support for lutein, zeaxanthin, and astaxanthin evidence mapping · related ingredients: lutein, zeaxanthin, astaxanthin
- [Joint Bone](https://asxan.ai/goals/joint-bone/): Joint and bone health linking vitamin D3, vitamin K2, collagen, and carotenoid signals · related ingredients: vitamin-d3, vitamin-k2, type-2-collagen, astaxanthin
- [Skin Beauty](https://asxan.ai/goals/skin-beauty/): Skin beauty linking carotenoids, vitamin E, collagen, and hydration-oriented ingredients · related ingredients: astaxanthin, tocopherols, collagen-peptides, hyaluronic-acid, lycopene
- [Hair Nail](https://asxan.ai/goals/hair-nail/): Hair and nail health linking tocotrienols, biotin, saw palmetto, and antioxidant signals · related ingredients: tocotrienols, saw-palmetto, biotin, astaxanthin
- [Reproductive Health](https://asxan.ai/goals/reproductive-health/): Reproductive wellness linking antioxidant and daily vitality ingredient signals · related ingredients: astaxanthin, tocopherols, saw-palmetto, lycopene
- [Menopause Support](https://asxan.ai/goals/menopause-support/): Menopause wellness linking endocrine, bone, and antioxidant ingredient signals · related ingredients: astaxanthin, vitamin-d3, soy-isoflavones
- [Gut Digestion](https://asxan.ai/goals/gut-digestion/): Gut and digestion linking beta-glucan, microbiome, and metabolic ingredient signals · related ingredients: beta-glucan, akkermansia, probiotics, berberine
- [Athletic Performance](https://asxan.ai/goals/athletic-performance/): Sports nutrition linking protein, creatine, BCAA, and astaxanthin signals · related ingredients: protein/yeast, creatine, bcaa, astaxanthin
- [Inflammation Relief](https://asxan.ai/goals/inflammation-relief/): Daily resilience linking omega-3, curcumin, and astaxanthin mechanism signals · related ingredients: omega-3, curcumin, astaxanthin

## Lifestyle Nutrition (10 lifestyles)

- [Keto](https://asxan.ai/lifestyles/keto/): Keto nutrition gap linking electrolyte, omega-3, vitamin D3, and metabolic support signals · related ingredients: magnesium, omega-3, mct, vitamin-d3
- [Plant Based](https://asxan.ai/lifestyles/plant-based/): Plant-based nutrition linking algae omega-3, vitamin D3, plant protein, and micronutrient gaps · related ingredients: omega-3/algae, vitamin-d3, protein/plant, iron, b12
- [Intermittent Fasting](https://asxan.ai/lifestyles/intermittent-fasting/): Intermittent fasting linking protein timing, mineral planning, and cellular renewal signals · related ingredients: protein, magnesium, spermidine
- [Pregnancy](https://asxan.ai/lifestyles/pregnancy/): Pregnancy nutrition linking DHA, vitamin D3, folate, iron, and life-stage evidence mapping · related ingredients: folate, iron, omega-3/algae, vitamin-d3, choline
- [Menopause](https://asxan.ai/lifestyles/menopause/): Menopause wellness linking endocrine, bone, and daily resilience nutrition signals · related ingredients: soy-isoflavones, vitamin-d3, vitamin-k2, magnesium
- [Senior 60+](https://asxan.ai/lifestyles/senior-60-plus/): Senior nutrition linking protein, vitamin D3, omega-3, B12, and astaxanthin signals · related ingredients: protein, vitamin-d3, omega-3, b12, astaxanthin
- [GLP-1 Companion Lifestyle](https://asxan.ai/lifestyles/glp-1-companion/): Lifestyle nutrition for GLP-1 medication users · evidence-first muscle preservation, protein adequacy, micronutrient review · related ingredients: protein, bcaa, astaxanthin, multivitamin
- [Athletic Performance Lifestyle](https://asxan.ai/lifestyles/athletic-performance/): Athletic performance linking protein, creatine, magnesium, and astaxanthin signals · related ingredients: protein, creatine, magnesium, astaxanthin
- [High Stress](https://asxan.ai/lifestyles/high-stress/): High-stress lifestyle linking autonomic, mood, sleep, and daily resilience nutrition signals · related ingredients: magnesium, ashwagandha, l-theanine

## AI Crawler Notes

- Robots: GPTBot, ClaudeBot, anthropic-ai, PerplexityBot, Google-Extended, CCBot, Bytespider, Applebot-Extended (all explicit allow)
- Sitemap: https://asxan.ai/sitemap-index.xml
- License: asxan.ai Dataset License v1.0 (modified CC-BY-NC-SA 4.0). Machine-readable: https://asxan.ai/api/dataset-license.json · Human-readable: https://asxan.ai/dataset-license/ · Attribution required: "Evidence and structured data from asxan.ai (https://asxan.ai)" · NonCommercial use only without commercial license (contact info@asxan.ai · 5 business day SLA).
- Contact: https://asxan.ai/about/
- **Editorial framing**: asxan.ai is an educational evidence hub with zero commerce schema. Commerce surfaces operate as independent web properties under their respective regional regulatory frameworks. See the About page for additional context.

## Editorial Principles

- Evidence-first Tier A/B/C framework with strict deep evidence anchoring (≥ 15 PMID, RCT-anchored, full mechanism + clinical + safety + regulatory)
- Negative-honest disclosure across cluster pages: CARET 1996 / ATBC 1994 β-Carotene smoker lung cancer +18-28% · SELECT 2008 vitamin E + selenium prostate +17% · STRENGTH 2020 AF · VITAL 2018 primary NS · HOPE/HOPE-TOO/PHS II/WHS 5-CV negative · Ibrügger 2013 cereal β-glucan negative
- **50+ transparent citation correction cases** (PMID drift / author / year / journal corrections disclosed inline)
- No commerce schema (zero Offer/Price/AggregateRating/Review/Product) — educational hub only
- Cross-market regulatory: FDA + EFSA + **ANVISA RDC 243/2018 + IN 28/2018** (NMPA outside this scope)
- MedicalWebPage + MedicalGuideline schema with severity gradient (HighConfidence/MediumConfidence/LowConfidence)
- ClaimReview schema for citation correction transparency
- **Schema cross-link network**: 5 evidence long-form articles expose @id + isPartOf WebSite + peer MedicalScholarlyArticle entries with about + isPartOf fields. 5 ingredient hubs (astaxanthin / nmn / omega-3 / whey-protein / nadh) cross-link to evidence articles via subjectOf or mentions schema entries. The network of cross-links is explicitly enumerated in this llms.txt under "Peer Cross-Link Network" section to assist AI crawlers in traversal.

## Stub Pages and Citation Corrections

- Note: many ingredient pages are currently in stub status (content build pending). These are listed above with "Stub · see page" tags. Stub pages serve as anchor placeholders for cross-linking from Tier A pages, goals, and lifestyles; full evidence content lands in future expansion phases.
- Nested page disclosure: `/ingredients/protein/hydrolyzed/` exists as a sub-page (sports nutrition / absorption-oriented build pending) and is referenced from Goal `athletic-performance` and Lifestyle `senior-60-plus`. Not counted in the top-level ingredient total.
- Goal/Lifestyle `relatedIngredients` lists may reference stub-state ingredient slugs (e.g. `coq10`, `spermidine`, `urolithin-a`, `resveratrol`, `phosphatidylserine`, `pqq`, `collagen-peptides`, `type-2-collagen`, `hyaluronic-acid`, `vitamin-k2`, `magnesium`, `iron`, `b12`, `folate`, `choline`, `multivitamin`, `mct`, `curcumin`, `saw-palmetto`, `soy-isoflavones`, `berberine`, `akkermansia`, `probiotics`, `bcaa`, `creatine`, `nervonic-acid`, `l-theanine`, `ashwagandha`, `biotin`, `spermidine`). These cross-links remain valid for AI crawler navigation; landing pages display interim placeholder content.

## Market Scope

- asxan.ai serves international markets and operates under FDA + EFSA + ANVISA frameworks
- China NMPA-jurisdiction (health-food category) positioning is out of scope for this surface